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Job Description

Boston, MA (hybrid) role at Vertex Pharmaceuticals offering an annual salary range of USD 166,640 - 250,000. This position focuses on building and productionizing AI-powered applications and agents end to end, with a delivery model that emphasizes fast, real-world impact through close collaboration with users, product, and business stakeholders.

Vertex provides an annual bonus, annual equity awards, comprehensive benefits including medical, dental, and vision, and generous paid time off, with a week-long company shutdown in the Summer and the Winter. The package also includes educational assistance programs (including student loan repayment), a generous commuting subsidy, matching charitable donations, and a 401(k).

Responsibilities

  • Design, build, and productionize full-stack AI applications, agents, and multi-step workflows for internal and user-facing use cases
  • Use a forward deployed engineering approach by partnering with end users, product teams, and business stakeholders to solve workflow problems quickly and effectively
  • Build agents that can reason across steps, invoke tools, call APIs, retrieve information, and take actions within defined enterprise guardrails
  • Own end-to-end delivery across user interfaces, application services, APIs, data access, agent orchestration, and integrations with internal platforms, third-party applications, and business-critical systems
  • Create reusable agent patterns, components, prompts, tools, and orchestration logic that can be scaled across use cases
  • Iterate on agent behavior based on usage data, qualitative feedback, evaluation results, and operational metrics
  • Improve agent quality through testing, experimentation, benchmarking, and structured measurement of outcomes
  • Partner with platform, integration, data, security, and product teams to support secure, reliable, maintainable agent solutions aligned with enterprise architecture
  • Help define best practices for agent design, tool use, fallback behavior, escalation paths, and human-in-the-loop workflows
  • Support the full software lifecycle including architecture, development, integration, deployment, monitoring, troubleshooting, and optimization in production environments
  • Contribute to observability for agent execution, including logging, tracing, performance tracking, and issue analysis
  • Design solutions with security, compliance, and responsible AI principles in mind
  • Stay current on emerging patterns, frameworks, and technologies in generative AI and agentic systems, translating them into practical applications for Vertex

Requirements

  • Bachelor’s degree in Computer Science, Software Engineering, Artificial Intelligence, Data Science, or a related technical field (equivalent practical experience may be considered)
  • Experience in full-stack software engineering, AI engineering, machine learning engineering, or intelligent application development
  • Hands-on experience building and operating production applications powered by large language models, AI workflows, or agentic systems
  • Experience delivering end-to-end applications across front-end, back-end, APIs, data stores, and enterprise systems
  • Demonstrated experience using AI-assisted software development and autonomous coding agents to design, generate, test, review, debug, optimize, and refactor code across complex enterprise systems
  • Deep understanding of AI-native software engineering practices, including establishing standards, governance, and best practices for responsible use of AI coding assistants and software engineering agents across engineering teams
  • Proven ability to move from prototype to production while balancing speed, quality, and operational rigor
  • Experience working directly with users or stakeholders to iteratively refine technical solutions based on real-world needs
  • Strong problem-solving and systems-thinking skills
  • Strong written and verbal communication skills, with the ability to collaborate effectively across technical and non-technical teams

Benefits

  • Eligible for an annual bonus
  • Annual equity awards
  • Some roles may also be eligible for overtime pay, in accordance with federal and state requirements
  • Medical, dental and vision benefits
  • Generous paid time off (including a week-long company shutdown in the Summer and the Winter)
  • Educational assistance programs including student loan repayment
  • Generous commuting subsidy
  • Matching charitable donations
  • 401(k)

Technical Skills

  • Full-stack application development across modern front-end and back-end technologies
  • Large language model application development
  • Agentic workflow design and orchestration
  • Prompt engineering and prompt iteration
  • Tool use and API integration for AI agents
  • Multi-step workflow automation
  • Rapid prototyping and productionization
  • Evaluation, testing, and quality measurement for AI systems
  • Application logging, monitoring, and observability
  • API design, service development, data modeling, and application architecture
  • Distributed systems and service integration
  • Secure software development practices
  • Enterprise application integration
  • Cloud-based application development
  • Version control, CI/CD, and deployment practices

Preferred Skills

  • Experience using a forward deployed engineering or similar embedded delivery model
  • Experience building internal copilots, assistants, or task-oriented AI agents
  • Familiarity with orchestration frameworks, agent runtimes, tool-calling architectures, and retrieval patterns
  • Experience integrating with enterprise collaboration tools, workflow systems, document platforms, or knowledge repositories
  • Familiarity with evaluation frameworks for AI quality, groundedness, task completion, and reliability
  • Experience designing human-in-the-loop workflows and safe failure or escalation mechanisms
  • Exposure to AI observability, tracing, and operational analytics
  • Experience in regulated industries such as biotechnology, pharmaceuticals, healthcare, or life sciences

Compensation and Flex Designation

Pay range: $166,640 - $250,000 per year.

Flex designation: Hybrid-Eligible or On-Site Eligible.

Flex eligibility status: For this hybrid-eligible role, you can choose to be designated as:

  • Hybrid: work remotely up to two days per week; or select
  • On-Site: work five days per week on-site with ad hoc flexibility

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

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