Associate Engineer, RNA Starting Material MS&T

The Associate Engineer, RNA Starting Material MS&T role at Sarepta Therapeutics in Andover, MA focuses on supporting synthesis, purification, analysis, and characterization of nucleoside-based and lipid building blocks for PMOs, next-generation PMO, and siRNA platforms, with involvement in development, scale-up, and tech transfer of RNA starting materials manufacturing.

Responsibilities

• Collaborate in a team performing lab-scale organic synthesis, purification, analysis, and characterization of nucleoside-based and lipid building blocks used in Sarepta's PMO, next-gen PMO, and siRNA platforms.
• Prepare reference markers and standards and contribute to supervised RNA starting materials manufacturing process chemistry development and scale-up projects to optimize routes and troubleshoot syntheses.
• Engage in cross-functional training, coordinate with Analytical/QC resources, and interpret data from HPLC, GC, KF, and NMR analyses.
• Draft experimental protocols and generate technical reports, applying strong organic chemistry knowledge and problem-solving skills.

Requirements

• Bachelor of Science in Chemical Engineering, Chemistry, or a related discipline, with 0-2 years of relevant experience.
• Solid grounding in organic chemistry and the ability to interpret data from GC, LC-MS, HPLC, NMR, and KF; practical experience running HPLC methods is strongly preferred.
• Ability to manage multiple tasks and meet deadlines in a fast-paced environment.
• Effective written and verbal communication skills.
• Strong interpersonal skills and meticulous attention to detail.
• May require up to 5% travel, domestically or internationally.

Technologies

• HPLC
• GC
• LC-MS
• NMR
• KF

Benefits

• Physical and Emotional Wellness
• Financial Wellness
• Support for Caregivers

The Importance of the Role

• Supports lab-scale synthesis, purification, analysis, and characterization of nucleoside-based and lipid building blocks for PMOs, next-generation PMO, and siRNA platforms.
• Contributes to the synthesis of reference markers and participates in supervised RNA starting materials process chemistry development and scale-up to optimize syntheses.
• Involves cross-functional training and regular collaboration with Analytical/QC teams, including interpretation of HPLC, GC, KF, and NMR data.
• Includes protocol writing and report generation, requiring strong organic chemistry and problem-solving capabilities.

The Opportunity to Make a Difference

• Support commercial supply assurance for RNA starting materials by synthesizing nucleoside reference markers and standards.
• Execute development studies independently or as part of a supervised team.
• Assess scalability of proposed changes and run experiments to mimic large-scale operations.
• Participate in technology transfer of improved processes to manufacturing sites.
• Build a solid understanding of Sarepta’s manufacturing processes to support process improvements, troubleshooting, and technology transfers.
• Perform synthesis and purification of nucleoside analogs to support production and development goals.
• Contribute to impurity profiling and collaborative efforts to characterize and manage impurities in intermediates.
• Use scientific judgment to identify likely sources of impurities and design experiments to test hypotheses within cross-functional teams.
• Compile data, interpret results, document study outcomes, and present conclusions.
• Attend vendor update meetings and provide input on ongoing vendor production projects.

More About You

• Bachelor of Science in Chemical Engineering, Chemistry, or related discipline, 0-2 years of experience.
• Technical competence in organic chemistry and familiarity with GC, LC-MS, HPLC, NMR, and KF data; experience running HPLC methods preferred.
• Able to multitask and meet deadlines in a dynamic setting.
• Strong written and verbal communication skills.
• Excellent interpersonal skills and careful attention to detail.
• May require travel up to 5 percent of time, domestically or internationally.